Pipeline

Cell Medica is committed to transforming the treatment of cancer through the use of cellular immunotherapy.  Through our internal development and collaborations and with leading academic research groups, we are working with three powerful technology platforms to generate safe and effective treatments to address a range of cancer types.   Our goal is to develop curative cell-based therapies that can be used safely and reliably for the benefit of patients.

Product
Autologous Product
Indication
Precl.
PH1
PH2
PH3
MKT
CMD-501
Neuroblastoma Small / cell lung cancer
Phase 1/2 - Q2 2018
 
 
 
 
 
CMD-503
Liver Cancer
Phase 1/2 - 2019
 
 
 
 
 
Allogeneic (Off the Shelf)
Indication
Precl.
PH1
PH2
PH3
MKT
Product
Indication
Precl.
PH1
PH2
PH3
MKT
Product
Indication
Precl.
PH1
PH2
PH3
MKT

CAR-NKT Cells

We are developing a platform for chimeric antigen receptor (CAR) technologies that allows for the production of multiple target-specific constructs.

CAR immune cell therapy is based on the selective ex vivo expansion of immune cells derived from patient peripheral blood and consists of four key steps:

  1. Harvesting the immune cells from the patient’s blood.
  2. Genetically engineering immune cells to express cancer-specific receptors.
  3. Increasing the number of engineered immune cells through ex vivo expansion.
  4. Infusing the functional cancer-specific immune cells back into the patient.

Through this process we are able to engineer immune cells that are capable of recognizing and killing cancer cells based on their proteins expressed on the surface of the cancer cell.

Dominant TCRs

Our T cell receptor (TCR) technology is currently in development and is a genetic approach to optimizing the function of TCRs.

The genes of the TCRs are isolated and modified before being introduced to T cells that would otherwise struggle to respond to the cancer or that lack a TCR capable of recognizing the cancer antigen.

We have developed a TCR construct that is capable of recognizing intracellular targets. We aim to optimize the activating capacity of the TCR to enhance anti-tumor activity.

EBV-targeted T Cells

Our T-cellerator technology enables us to generate patient-derived (autologous) expanded T cells specific to Epstein-Barr virus (EBV), our CMD-003 product, and adapt the cells to express improved functionality even in the hostile micro-environment of a tumor.

The manufacturing process starts with the isolation of peripheral blood mononuclear cells (PBMCs) from a patient-derived whole blood sample. T cells in the PBMC fraction are then stimulated with autologous dendritic cells (DCs) and overlapping peptide pools of EBV antigens.

The process also involves expansion steps to obtain cell numbers sufficient for clinical applications and utilises additional cell types such as DCs and also cytokines.

The final product is formulated, cryopreserved and stored prior to shipment to the clinical site for infusion.