to: Chief Scientific Officer
To lead the development of viral and non-viral vectors
to engineer T and NKT cells to treat human cancers. The candidate will
interface between research and product development and will be responsible not
just for the engineering of the vectors but also for providing key guidance for
process development and GMP manufacturing of the vectors moving into the
clinic. The successful candidate will have in-depth expertise of retrovirus,
lentivirus and AAV viral vector design as well as non-viral vector design and
their application for cellular immunotherapies. The purpose of this position is
to provide hands-on experience from vector selection, construction, and
production to the development and implementation of innovative analytical
technologies for vector characterization. This position is full time and based in Schlieren, Zurich.
and implementation of a scientific strategy for vector selection and
hands-on cutting-edge research to develop viral and non-viral vectors to
support various cellular therapy platforms.
vector cassette and support scale-up production in support of clinical
oversight/management of outsourced vector development and production of
clinical trial material.
with senior management and project managers to enable the development and
technology transfer of viral/non-viral vector processes.
manage, analyse and present critical data in a highly organized manner.
knowledge of vector biology to optimize gene delivery into primary and cultured
development protocols, reports and SOPs to support technology development, transfer
and regulatory submissions.
Participate in the evaluation of advanced technologies for vector bioprocessing, potential in-licensing opportunities and the identification of external collaborators.
Demonstrate accuracy and attention to detail
in data analysis and data management.
• The ideal candidate for this position is expected to spend a significant fraction of his/her time in the laboratory leading and supporting the development and production of viral and non-viral vectors.
• Industry experience in Biotech or Pharma is desirable, but we will consider candidates with relevant academic experience. Experience working with chimeric antigen receptors and adoptive cell therapies is highly desirable.
PhD in a related biological science, with post-doctoral training and research experience in the field of virology at the molecular, biological and gene delivery level for cellular immunotherapies.
Minimum of 2-5 years' previous experience or equivialnt experienceworking in the development of cell and gene therapies using viral and/or non-viral vectors, preferablyinan industry setting.
with upstream and downstream bioprocessing of vectors including viral vector
biology and cell line development.
working with GMP regulations to manufacture viral vectors for cellular
cell culture of human and/or mammalian cell lines using a variety of static
culture systems and/or bioreactors is essential.
chromatography, filtration and other separation / purification techniques is a
the development of analytical assays suitable for use as characterization, QC
release methods and in-process controls.
tech transfer to/from commercial and research organizations.
viral vectors used in the ex vivo and in vivo modification of products is
writing and carrying out GMP production protocols is desirable.
motivated and demonstrate the ability to work effectively as part of a multi-disciplinary
â€¢ Team and service oriented
â€¢ Highly organized
â€¢ Dependable and meets commitments
â€¢ Quality and detail oriented with high standards
â€¢ Strong planning and organizational skills, verbal, written
â€¢ Well-developed communication skills, good at listening and sharing information with others
â€¢ Ability to act on own initiative within inter-related team communication
â€¢Excellent verbal and written English language is essential
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